Regenerative Medicine

Regenerative medicine is an emerging field in the medical community. Basically, regenerative medicine encompasses treatment modalities that create conditions within the body that promote healing of damaged tissues. Whereas conventional medicine can be very effective in the control of infection through the use of antibiotics and the management of pain by using analgesic drugs, the job of truly healing damaged tissues has traditionally been left up to the patient’s own innate abilities. Regenerative medicine has the potential to change that paradigm.

Sometimes conditions arise that are difficult or impossible for the body to heal on its own. Trauma/ damage to internal organs, the brain and spinal cord, or degenerative conditions that come with age often come with delayed or absent healing. Through the use of the regenerative therapies below as well as other holistic modalities, we now have the ability to stimulate healing and improve patient health in ways previously considered impossible.

We offer regenerative medicine modalities such as:

  • Hyperbaric Oxygen Therapy
  • Stem Cell Therapy
  • Pulsed Signal Therapy
  • Pulsating Electromagnetic Field Therapy (PEMF)

Holistic Veterinary Care is pioneering the integration of conventional Western medicine, holistic medicine, and now regenerative medicine to provide pets with unparalleled access to health and wellness care that promotes long and healthy lives for our patients.

Call 510-339-2600 today for an appointment where you can expect clear communication and a gentle approach. As pet owners ourselves, we understand the stress and emotion involved when a pet is sick or in pain. We do our best to make sure your concerns are heard and addressed at the deepest possible level.

Hyperbaric Oxygen Therapy

One hundred percent oxygen delivered under controlled pressure in a Hyperbaric Oxygen Chamber has shown healing benefits for your pet’s conditions.  These include:

  • Wounds/burns
  • Head/Spinal Cord Trauma
  • Stem Cell Therapy
  • Post Surgical Swelling
  • Crush Injuries
  • Pancreatitis
  • Necrosis
  • Heat Stroke
  • Snake/Spider Bites
  • Bone Infection
  • Smoke Inhalation
  • Sinusitis

…and many more

What You Can Expect During Your Pet’s Hyperbaric Oxygen Therapy Treatment

Treatments may last from 1 to 2 hours and are given 1 to 3 times daily with at least 4 hours between sessions.  Most patients appear calm and relaxed during Hyperbaric Oxygen Therapy.  Many even fall asleep!  Generally Hyperbaric Oxygen Therapy results in:

  • Reduction in swelling
  • Stimulation of new blood vessel formation into the healing/swollen tissue
  • Reduction in pressure caused by head or spinal cord injuries
  • Improved would healing
  • Improved infection control
“Hyperbaric oxygen therapy can be of great help to veterinary patients by speeding up the healing process and may reduce or eliminate the need for more invasive procedures such as surgery, often times resulting in a net savings of time and cost of treatment for pet owners.”
- Dr. Richter, Medical Director of Holistic Veterinary Care

Celebrate this new technology for your pet’s quality and quantity of life.  This Hyperbaric Oxygen chamber can make a difference in not only the quality of your pet’s life, but also helping them live longer.


Alec Receiving Hyberbaric Oxygen Therapy at Holistic Veterinary Care

In addition to the conditions above, HBOT is well documented to stimulate stem cell activity in the body. This creates a great potential synergism when HBOT is combined with stem cell therapy. While this synergism has not been well studied yet, there is great promise that we may be able to effectively treat diseases that until now, had no effective treatment. This is truly cutting edge medicine.

Hyperbaric Oxygen Therapy (HBOT) has been used in human medicine for years in the treatment of acute and chronic diseases that suffer from a lack of oxygen.  Safely and painlessly, oxygen delivered to the patient in the hyperbaric chamber is inhaled and absorbed by the body at pressure many times greater than when breathing oxygen at normal sea level pressure. Under hyperbaric pressure, healing oxygen is dissolved in the blood plasma, cerebrospinal and lymph fluids, enabling oxygen to reach damaged tissue at least 3 to 4 times farther than normally diffused by red blood cells. This is especially important in swollen and inflamed tissues where small blood vessels have been spread apart and oxygen from red blood cells is unable to diffuse out far enough to supply the needs of damaged cells.

The application for HBOT in veterinary medicine are much the same as in human medicine: increased oxygen delivery to cells in the body. The result of the increased delivery of oxygen to damaged tissues is the relief of inflammation, pressure and edema caused by injury or infection. In addition, the increased levels of oxygen promotes angiogenesis (new blood vessel formation), stimulates wound healing and can help the body fight infection. Below is a much more detailed list of the medical conditions that benefit from HBOT:

•    Head trauma swelling reduction - immediate
•    Brain tumor swelling reduction
•    Intervertebral disc disease - reduce acute inflammation
•    Intracranial abscessation/granuloma
•    Cerebral edema
•    Acute nerve injury/crush or trauma
•    Cutaneous, decubitus and stasis ulcers
•    Stroke victims
•    Tetanus
•    Degenerative myelopathies

Emergency medicine
•    Acute carbon monoxide intoxication
•    Acute traumatic peripheral ischemia
•    Crush injuries
•    Laryngeal paralysis crisis
•    Exceptional blood loss crisis
•    Severe soft tissue infections
•    Thermal burns
•    Smoke inhalation
•    Cardiogenic shock
•    Aerobic or anaerobic septicemia
•    Myocardial infarction
•    Pulmonary emphysema
•    Pancreatitis
•    Pyothorax
•    Near drowning
•    Snake bites

Internal medicine
•    Gangrene
•    Progressive necrotizing infections
•    Osteomyelitis
•    Clostridial myositis
•    Radiation injury or post radiation therapy
•    Cognitive performance and age related cognitive dysfunction
•    Hepatic necrosis
•    Severe rhinitis/sinusitis

•    Skin grafts and flaps
•    All non-healing wounds
•    Wound healing enhancement
•    Post-operative swelling
•    Arthritic disease
•    Swelling associated with fractures/trauma

Stem Cell Therapy

Stem cells are cells within our bodies that have the ability transform into different cell types depending on what is required of them. For example, a stem cell might turn into a heart cell if the heart is damaged. It may turn into a kidney cell if there is kidney damage, etc. While we all have stem cells in our body, recent advances in science allow us to concentrate and activate these cells to stimulate regeneration of damaged tissues and organs within a patient.

In order to utilize stem cells in the treatment of disease, they must first be collected in a quick surgical procedure. Fatty tissue within the body contains a very high concentration of stem cells. A small amount of fat is collected and then processed to concentrate and activate the stem cells within. Those cells are then given back to the patient either intravenously or directly at the sight of the injury or damaged tissue. In addition to directly helping to heal tissues, stem cells have a systemic effect that decreases inflammation and mobilizes more stem cells within the body to promote healing.

Stem cell therapy is most commonly used for orthopedic conditions such as arthritis, and damaged ligaments and tendons.  There are many other potential applications still being explored such as kidney and other organ diseases, cognitive dysfunction, and the treatment of chronic inflammatory processes. 

In addition to benefiting your pet at the time the stem cells are administered, they can be banked for future use.  One collection of fat can yield four or more treatments of stem cells.  The cells can be banked and used in the future if they are needed.

Pulsed Signal Therapy

Pulsed Signal Therapy (PST) is a new medical treatment for small animals that effectively treats osteoarthritis, hip dysplasia, degenerative joint disease, rheumatoid disease, back pain and sports-type injuries. PST significantly relieves the severity of joint pain, tenderness and swelling. It also improves mobility, allows for restful sleep and restores the activities of daily living without drugs or surgery. Studies have shown that PST offers long-term positive results.

PST consists of pulsed signals that mimic the normal healthy physiological signals transmitted by the body into the joints. This promotes the repair of damaged cells and stimulates the body’s natural repair and maintenance processes. Treatment using prescription medication often focuses on alleviating symptoms. Pulsed Signal Therapy, instead, concentrates on the root cause of the symptoms: the breakdown of cartilage and joint tissue. Pain and swelling can occur when the cartilage wears because of degenerative joint disease, overuse or injury. Pulsed Signal Therapy reproduces the bio-physically correct restoration signal and directs it into the joint. This stimulates the existing cartilage and other damaged structures to repair themselves and function more efficiently. It also accelerates the convalescent period and restores joint function.


Pets receive nine half-hour treatment sessions that take place on consecutive days. The joint or body area is positioned within the PST device, which emits the bio-physiological pulsed signal. Pulsed Signal Therapy is always administered under the prescription and supervision of a veterinarian. The goal is short- and long-term pain reduction and a return to full functionality, all while improving the pet’s quality of life. Pulsed Signal Therapy is a non-invasive, totally painless therapeutic modality without any known or reported side effects. The overall cost of PST is comparable to that of long-term non-steroidal anti-inflammatory drugs (NSAIDS) such as Rimadyl®, Metacam or analgesic drug use.

PST technology was developed by biophysicist and medical doctor Richard Markoll, MD, PhD. Initial double-blind placebo-controlled clinical studies conducted on humans under the direction of the Yale University School of Medicine and published in the highly respected Journal of Rheumatology, indicate that more than 70 percent of patients treated showed a significant improvement. Clinical studies conducted around the world have confirmed the initial results. To date, more than a half million people and thousands of animals have received PST treatment at 750 clinics worldwide.

Additional Resources

Journal of Rheumatology Report

US Patent

American Academy of Pain Management Report

Pulsed Signal Therapy Vancouver

Assisi Pulsating Electromagnetic Field

All living beings are in essence an electrical system. Pulsating Electromagnetic Field (PEMF) technology is a fascinating science utilizing the body’s ability to recognize electromagnetic energy in order to stimulate healing. The Assisi PEMF device is approved by the FDA for use in humans with non-healing wounds. The energy signature produced by the device stimulates the production of nitric oxide, which through a cascade of events promotes the growth of new blood vessels (angiogenesis). When blood flow is improved to an area of injury, the result is reduced pain and inflammation as well as increased speed of tissue healing.

We use the Assisi PEMF as a targeted therapy for animals with pain due to orthopedic diseases as well as spinal and neurologic pain. It has also been successfully used in patients with neurologic impairments due to spinal compression and to help relieve the pain associated with intervertebral disc disease. The Assisi device is small and portable which makes it ideal to be used daily in a home setting.



Below is a collection of scientific articles that pertain to the use of Hyperbaric Oxygen Therapy for the benefit of internal medicine, neurology, oncology, and surgery patients.

Internal Medicine Journal Articles

Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review

Anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test

Hyperbaric oxygen improves capillary morphology in severe acute pancreatitis

Hyperbaric oxygen therapy reduces severity and improves survival in acute pancreatitis

Hyperbaric oxygenation as an adjunct therapy in strokes due to thrombosis

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo

Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis

Hyperbaric oxygen therapy for interstitial cystitis resistant to conventional treatments

Hyperbaric oxygen in the treatment of invasive fungal infections: a single-center experience

Protection of mitochondrial function and improvement in cognitive recovery in rats

Effects of hyperbaric exposure w/high oxygen concentration on insulin levels of diabetic rats

Neurology Journal Articles

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Effect of hyperbaric oxygenation on intervertebral disc degeneration: an in vitro study w/lumbar

Attenuating experimental spinal cord injury by hyperbaric oxygen

Hyperbaric oxygen induces endogenous neural stem cells to proliferate in brain damaged rats

Hyperbaric oxygen therapy for traumatic brain injury

Hyperbaric oxygen treatment induces antioxidant gene expression

Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis

Neuroprotection by oxygen in acute transient focal cerebral ischemia

Hyperbaric oxygen in the treatment of invasive fungal infections: a single-center experience

Protection of mitochondrial function and improvement in cognitive recovery in rats

Preconditioning w/hyperbaric oxygen attenuates brain edema after intracerebral hemorrhage

Oncology Journal Articles

Prospective assessment of patients treated with HBOT for chronic radiation tissue injury

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma

HBOT reduces COX-2 expression in a dimethylhydrazine-induced rat of colorectal carcinogenesis

Role of elevated pressure in TRAIL-induced apoptosis in human lung carcinoma cells

Hypoxic radiosensitization: adored and ignored

Lung metastatic load limitation with hyperbaric oxygen

Hyperbaric oxygen treatment induces antioxidant gene expression

Surgery Journal Articles

Oxygen in wound healing: nutrient, antibiotic, signaling molecule, and therapeutic agent

HBOT stimulated growth of osteoblasts mediated through the FGF-2/MEK/ERK pathways

Hyperbaric oxygen therapy in femoral head necrosis

Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns

HBOT is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Effects of HBOT and platelet derived growth factor on medial collateral ligament fibroblasts

Evaluation of hyperbaric oxygen therapy in treatment of patients with osteomyelitis of the mandible

Hyperbaric oxygen in the treatment of invasive fungal infections: a single-center experience

Effects of HBOT on proliferation and differentiation of osteoblasts from human alveolar bone

Effects of hyperbaric oxygen on gene expressions of procollagen, matrix metalloproteinase and tissue inhibitor of metalloproteinase in injured medial collateral ligament and anterior cruciate ligament

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